Valecobulin hydrochloride

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Valecobulin Hydrochloride 是 β-微管蛋白聚合的有效抑制剂。

Valecobulin hydrochloride is a potent inhibitor of β-tubulin polymerization. Valecobulin hydrochloride is a valine prodrug and a vascular disrupting agent.(In Vivo):In male BALB/C nu/nu mice, Valecobulin hydrochloride (5 mg/kg; i.p) showed markedly antitumor efficacy in various human tumor xenograft models.

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Valecobulin (5 mg/kg; intraperitoneal injection; administered on days 2, 6, 10, and 14; male BALB/C nu/nu mice) treatment shows markedly antitumor efficacy in various human tumor xenograft models. Animal Model:Male BALB/C nu/nu mice (5-6 weeks of age) with HCT-116 or HCT-15 cells Dosage:5 mg/kg Administration:Intraperitoneal injection; administered on days 2, 6, 10, and 14 Result:Had shown marked antitumor efficacy in various human tumor xenograft models.

CKD-516 hydrochloride

Cytoskeleton/Cell Adhesion Molecules

Microtubule/Tubulin

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1240321-53-2

573.07

C26H29ClN6O5S

>98% (HPLC)

In Vitro:?DMSO : 125 mg/mL (218.13 mM)

Cl.COc1cc(cc(OC)c1OC)C(=O)c1ccc(cc1-n1cncn1)-c1csc(NC(=O)[C@@H](N)C(C)C)n1

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(-20℃)

With Ice Pack

≥ 2 years